The 5-HT3A receptor is essential for fear extinction
نویسندگان
چکیده
منابع مشابه
The 5-HT3A receptor is essential for fear extinction.
The 5-HT3 receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT3A receptor knockout mice in fear conditioning paradigms revealed that the 5-HT3A receptor is not required for the acquisition or retention of fear memory but is essential ...
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In some individuals, fearful experiences (e.g., combat) yield persistent and debilitating psychological disturbances, including posttraumatic stress disorder (PTSD). Early intervention (e.g., debriefing) after psychological trauma is widely practiced and argued to be an effective strategy for limiting subsequent psychopathology, although there has been considerable debate on this point. Here we...
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ژورنال
عنوان ژورنال: Learning & Memory
سال: 2013
ISSN: 1072-0502,1549-5485
DOI: 10.1101/lm.032193.113